Israel attacked Iran's capital early Friday in strikes that targeted the country's nuclear program and killed at least two top military officers, raising the potential for an all-out war between the two bitter Middle East adversaries. It appeared to be the most significant attack Iran has faced since its 1980s war with Iraq.

The strikes came amid simmering tensions over Iran’s rapidly advancing nuclear program and appeared certain to trigger a reprisal, with Supreme Leader Ayatollah Ali Khamenei warning that “severe punishment” would be directed at Israel. Hours later, Israel's military said it had begun intercepting Iranian drones launched in retaliation.

An Israeli official said the interceptions were taking place outside of Israeli territory, but did not elaborate. The official spoke on condition of anonymity pending a formal announcement.

Iraq said more than 100 Iranian drones had crossed its airspace, and a short time later neighboring Jordan said its air force and defense systems had intercepted several missiles and drones that had entered its airspace for fear they would fall in its territory.

Israel's attack on Iran hit several sites, including the country's main nuclear enrichment facility, where black smoke could be seen rising into the air. Later in the morning, it said it had also destroyed dozens of radar installations and surface-to-air missile launchers in western Iran.

The leader of Iran's paramilitary Revolutionary Guard, Gen. Hossein Salami, was confirmed dead, Iranian state television reported, a development that is a significant blow to Tehran's governing theocracy and an immediate escalation of its long-simmering conflict with Israel.

The chief of staff of Iranian armed forces, Gen. Mohammad Bagheri, was also confirmed dead by Iranian state television. Other top military officials and scientists were believed to have been killed.

In Washington, the Trump administration, which had cautioned Israel against an attack during continued negotiations over Iran's nuclear enrichment program, said that it had not been involved and warned against any retaliation targeting U.S. interests or personnel.

Still, it seemed likely the U.S. suspected an attack could be in the offing, with Washington on Wednesday pulling some American diplomats from Iraq’s capital and offering voluntary evacuations for the families of U.S. troops in the wider Middle East.

Israel calls attacks preemptive strikes on Iran’s nuclear program

Israeli leaders cast the preemptive assault as a fight for the nation's survival that was necessary to head off an imminent threat that Iran would build nuclear bombs, though it remains unclear how close the country is to achieving that or whether Iran had actually been planning a strike soon.

“It could be a year. It could be within a few months," Prime Minister Benjamin Netanyahu said as he vowed to pursue the attack for as long as necessary to “remove this threat.”

"This is a clear and present danger to Israel’s very survival,” he said.

Israel is believed to have carried out numerous highly secretive attacks on Iranian soil over the years, though it has rarely acknowledged them. Most have been aimed at Iran’s nuclear program, though Iran has also accused Israel of targeting its natural gas pipelines and of assassinating Hamas political leader Ismail Haniyeh in Tehran.

Over the past year, Israel has also been targeting Iran’s air defenses, hitting a radar system for a Russian-made air defense battery in April 2024 and surface-to-air missile sites and missile manufacturing facilities in October.

Some 200 Israeli aircraft took part in Friday's operation, hitting about 100 targets, Israeli army chief spokesman Brig. Gen. Effie Defrin said, adding that the attacks were ongoing.

In the aftermath, Defrin said Iran had launched more than 100 drones toward Israel and that "all the defense systems are acting to intercept the threats.”

Israel, Iraq, Iran and Jordan shut down their airspace to all flights as a precaution.

Iran confirms top officials and scientists killed.

Khamenei issued a statement carried by the state-run IRNA news agency. It confirmed that top military officials and scientists had been killed in the attack.

Israel “opened its wicked and blood-stained hand to a crime in our beloved country, revealing its malicious nature more than ever by striking residential centers,” Khamenei said.

For Netanyahu, the operation distracts attention from Israel’s ongoing and increasingly devastating war in Gaza, which is now over 20 months old.

There is a broad consensus in the Israeli public that Iran is a major threat, and Israel’s opposition leader, Yair Lapid, a staunch critic of Netanyahu, offered his “full support” for the mission against Iran. But if Iranian reprisals cause heavy Israeli casualties or major disruptions to daily life, Netanyahu could see public opinion quickly shift.

Netanyahu expressed hope the attacks would trigger the downfall of Iran’s theocracy, saying his message to the Iranian people was that the fight was not with them, but with the “brutal dictatorship that has oppressed you for 46 years.”

“I believe that the day of your liberation is near,” the Israeli leader said.

Multiple sites in the Iranian capital were hit in the attack, which Netanyahu said targeted both nuclear and military sites. Also targeted were officials leading Iran’s nuclear program and its ballistic missile arsenal. The International Atomic Energy Agency confirmed that an Israeli strike hit Iran’s uranium enrichment facility at Natanz and said it was closely monitoring radiation levels.

The strike on Iran pushed the Israeli military to its limits, requiring the use of aging air-to-air refuelers to get its fighter jets close enough to attack. It wasn’t immediately clear if Israeli jets entered Iranian airspace or just fired so-called “standoff missiles” over another country. People in Iraq heard fighter jets overhead at the time of the attack. Israel previously attacked Iran from over the border in Iraq.

Tension had been growing for weeks ahead of attacks

The potential for an attack had been apparent for weeks as angst built over Iran's nuclear program.

President Donald Trump on Thursday said that he did not believe an attack was imminent but also acknowledged that it “could very well happen.” Once the attacks were underway, the U.S. Embassy in Jerusalem issued an alert telling American government workers and their families to shelter in place until further notice.

U.S. Secretary of State Marco Rubio said Israel took “unilateral action against Iran” and that Israel advised the U.S. that it believed the strikes were necessary for its self-defense.

“We are not involved in strikes against Iran, and our top priority is protecting American forces in the region,” Rubio said in a statement released by the White House.

Trump is scheduled to attend a meeting of his National Security Council on Friday in the White House Situation Room, where he is expected to discuss the conflict with top advisers. It is not clear if he plans to make public remarks on the strikes.

Israel has long been determined to prevent Iran from developing nuclear weapons, a concern laid bare on Thursday when the Board of Governors at the International Atomic Energy Agency for the first time in 20 years censured Iran over its refusal to work with its inspectors. Iran immediately announced it would establish a third enrichment site in the country and swap out some centrifuges for more-advanced ones.

Even so, there are multiple assessments on how many nuclear weapons it could conceivably build, should it choose to do so. Iran would need months to assemble, test and field any weapon, which it so far has said it has no desire to do. U.S. intelligence agencies also assess Iran does not have a weapons program at this time.

In a sign of the far-reaching implications of the emerging conflict, Israel's main airport was closed and benchmark Brent crude spiked on news of the attack, rising nearly 8%. Both Iran and Israel closed their airspace.

Israeli Defense Minister Israel Katz warned that in the aftermath of the strikes, “missile and drone attacks against Israel and its civilian population are expected immediately.”

“It is essential to listen to instructions from the home front command and authorities to stay in protected areas,” he said in a statement.

As the explosions in Tehran started, Trump was on the lawn of the White House mingling with members of Congress. It was unclear if he had been informed, but the president continued shaking hands and posing for pictures for several minutes.

Trump earlier said he urged Netanyahu to hold off on any action while the administration negotiated with Iran over nuclear enrichment.

“As long as I think there is a (chance for an) agreement, I don’t want them going in because I think it would blow it,” Trump told reporters.

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Israeli strikes kill Iran's Revolution Guard leader, Gen. Hossein Salami

Chief of Iran's paramilitary Revolutionary Guard Gen. Hossein Salami.

Iranian state television confirmed the head of the paramilitary Revolutionary Guard was killed in Israel's strikes Friday morning.

Gen. Hossein Salami was the chief of one of the country's most powerful centers, and his death was a tough blow to Iran's embattled leadership, which has had a series of setbacks in the past 20 months of Middle Eastern war and unrest.

Salami rose to power six years ago and had a history of threatening the U.S. and Israel.

Here's a closer look.

Powerful arsenal of missiles

Iran’s Revolutionary Guard was created after its 1979 Islamic Revolution. Since it was established, it's evolved from a paramilitary, domestic security force to a transnational force that has come to the aid of Tehran’s allies in the Mideast, from Syria and Lebanon to Iraq.

It operates in parallel to the country's existing armed forces and controls Iran’s arsenal of ballistic missiles, which it has used to attack Israel twice during the Israel-Hamas war in the Gaza Strip.

Salami, 65, was appointed as head of the guard in 2019 by the country's supreme leader, Ayatollah Ali Khamenei.

The appointment followed U.S. President Donald Trump's decision during his first term to withdraw the U.S. from the international nuclear deal with Iran and restore crippling sanctions. It also followed Trump's designation of the Guard as a terrorist organization.

Salami joined the guard at the outbreak of the bloody 1980s Iran-Iraq war. He later rose to head its air forces and was serving as a deputy commander in the guard when he was appointed.

Harsh rhetoric

Like other guard leaders, Salami routinely delivered speeches with harsh rhetoric towards Israel. In a 2016 speech he said there was “fertile ground” for the “annihilation, the wiping out, and the collapse of the Zionist regime”.

He also threatened the United States.

After the U.S. killed the powerful head of the guard's Quds Force, Qassem Soleimani, in a drone strike outside Baghdad's airport in 2020, Salami threatened to retaliate against American and Israeli commanders. The Quds, or Jerusalem, Force is an elite wing of the Guard that oversees foreign operations.

Five days later, Iran launched ballistic missiles at two bases in Iraq housing American troops, causing injuries but no fatalities among soldiers there.

After Soleimani was killed, Salami said that both the U.S. and Israel should know that “if they threaten our commanders, none of their commanders will find a safe place” to live.

Emerging from the shadow war

Israel and Iran have run a shadow war for years, but last year the two attacked each other directly.

When an Israeli strike killed seven guard members, including two Iranian generals at an Iranian diplomatic compound in Syria, Salami vowed to retaliate.

Weeks later, Salami ordered an operation that launched more than 300 drones, ballistic missiles and cruise missiles in an unprecedented revenge mission that pushed the Middle East closer to a regionwide war.

Israel said that 99% were intercepted with several ballistic missiles reaching Israeli territory, causing minor damage to an air base.

In October Israel pounded Iran with a series of airstrikes in response to missile attacks into Israel from Iran earlier in the month.

Israel's military said it targeted “missile manufacturing facilities used to produce the missiles that Iran fired at the state of Israel over the last year.” Israel also weakened the country's air defenses, which helped clear the way for Friday's attacks.