Israel’s defense minister warned Saturday that “Tehran will burn” if Iran continues firing missiles, as the countries traded blows a day after Israel launched a blistering surprise attack on Iranian nuclear and military sites, killing several top generals.

The attacks have left Iran’s surviving leadership with the difficult decision of plunging deeper into conflict with Israel’s more powerful forces or seeking a diplomatic route.

The ongoing Israeli strikes appear to have halted — for now — any diplomacy between the U.S. and Iran over Tehran’s rapidly advancing nuclear program. Israel and Iran signaled more attacks are coming despite urgent calls from world leaders to deescalate to avoid all-out war.

The region is already on edge as Israel makes a new push to eliminate the Iranian-backed militant group Hamas in Gaza after 20 months of fighting.

Israel — which is widely believed to have a nuclear weapons program — said its hundreds of strikes on Iran over the past two days also killed nine senior scientists and experts involved in Iran’s nuclear program. Iran’s U.N. ambassador said 78 people were killed and more than 320 wounded.

Iran retaliated by launching waves of drones and ballistic missiles at Israel, where explosions lit the night skies over Jerusalem and Tel Aviv and shook buildings. The Israeli military urged civilians, already rattled by the war in Gaza sparked by Hamas’ Oct. 7 attack, to head to shelter for hours. Health officials said three people were killed and dozens wounded.

Defense Minister Israel Katz said Iran will pay a heavy price for harming Israeli citizens. "If (Iranian Supreme leader Ayatollah Ali) Khamenei continues to fire missiles at the Israeli home front — Tehran will burn,” Katz said.

Prime Minister Benjamin Netanyahu said Friday that his objective was to eliminate any Iranian threat to Israel, but he also urged Iranians to rise up against their leaders.

Strikes could derail nuclear talks-

The U.S. and Iran were scheduled to be in Oman on Sunday for their sixth round of indirect talks over Iran's nuclear program. Iran’s top diplomat said Saturday the talks were “unjustifiable” after the Israeli strikes, likely signaling no negotiations this weekend. But he stopped short of saying the talks were canceled.

The comments by Abbas Araghchi, Iran's minister of foreign affairs, came during a call with Kaja Kallas, the European Union’s top diplomat.

The Israeli airstrikes were the “result of the direct support by Washington,” Araghchi said in a statement carried by the state-run IRNA news agency. The U.S. has said it isn’t part of the strikes.

There was no immediate word from the White House after Araghchi's comments. On Friday, U.S. President Donald Trump urged Iran to reach a deal with the U.S. on its nuclear program. He warned on social media that Israel’s attacks “will only get worse,” adding that "Iran must make a deal, before there is nothing left.”

Iranian missiles strike Israel-

Khamenei signaled in a recorded message Friday that Iran was prepared to keep up its retaliatory attacks on Israel: “We will not allow them to escape safely from this great crime they committed.”

Iran launched waves of missiles at Israel late Friday and early Saturday, and Iranians awoke to state television airing repeated clips of strikes on Israel, as well as videos of people cheering and handing out sweets.

The Iranian attacks killed at least three people and wounded 76, mostly in and around Tel Aviv, according to two local hospitals. One missile severely damaged at least four homes in the nearby city of Rishon Lezion, according to first responders.

The Israeli military said seven soldiers were lightly wounded when a missile hit central Israel, without specifying where. It was the first report of Israeli military casualties since the initial Israeli strikes.

U.S. ground-based air defense systems in the region were helping to shoot down Iranian missiles, said a U.S. official who spoke on condition of anonymity to discuss the measures.

In Ramat Gan, east of Tel Aviv, an Associated Press journalist saw burned-out cars and at least three damaged houses, including one whose front was nearly entirely torn away.

Residents of a central Israeli city that was hit Friday night told the AP the explosion was so powerful it shook their shelter door open. “We thought, that’s it, the house is gone, and in fact half of the house was gone,” said Moshe Shani.

Israeli police said debris from the interception of drones and missiles fell in dozens of locations in northern Israel, causing damage and fires but no injuries.

Israel’s main international airport said Saturday it will remain closed until further notice.

Indications of a new Israeli attack

Iranian state television reported online that air defenses were firing in the cities of Khorramabad, Kermanshah and Tabriz. Footage from Tabriz showed black smoke rising from the city.

An Israeli military official said Saturday that the military was poised to carry out more strikes in Iran, saying, “This is not over.” He spoke on condition of anonymity in line with official procedures.

Israel's army spokesman, Brig. Gen. Effie Defrin, said Israel had attacked more than 400 targets across Iran, including 40 in Tehran, where dozens of fighter jets were “operating freely.” He said it was the deepest point Israel's air force had operated.

Defrin said fighter jets struck over 40 “missile-related targets and advanced air defense array systems” across Iran.

Overnight, the sound of explosions and Iranian air defense systems firing at targets echoed across central Tehran. Iran’s semiofficial Tasnim news agency reported a fire at Tehran’s Mehrabad International Airport.

Countries in the region condemned Israel’s attack, while leaders around the globe called for immediate deescalation from both sides.

‘More than a few weeks’ to repair nuclear facilities

Among the key sites Israel attacked was Iran’s main nuclear enrichment facility in Natanz. Satellite photos analyzed by AP show extensive damage there. The images shot Saturday by Planet Labs PBC show multiple buildings damaged or destroyed. The structures hit include buildings identified by experts as supplying power to the facility.

U.N. nuclear chief Rafael Grossi told the Security Council that the above-ground section of the Natanz facility was destroyed. The main centrifuge facility underground did not appear to have been hit, but the loss of power could have damaged the infrastructure there, he said.

Israel said it also struck a nuclear research facility in Isfahan, including “infrastructure for enriched uranium conversion,” and said it destroyed dozens of radar installations and surface-to-air missile launchers in western Iran. Iran confirmed the strike at Isfahan.

The Israeli military official said that according to the army's initial assessment “it will take much more than a few weeks” for Iran to repair the damage to the Natanz and Isfahan nuclear sites. The official said the army had “concrete intelligence that production in Isfahan was for military purposes.”

Israel denied it had struck the nuclear enrichment facility in Fordo, about 100 kilometers (60 miles) southeast of Tehran, after an Iranian news outlet close to the government reported the sound of explosions nearby,

Netanyahu said the attack had been months in the making and was planned for April before being postponed.

Among those killed were three of Iran’s top military leaders: one who oversaw the entire armed forces, Gen. Mohammad Bagheri; one who led the paramilitary Revolutionary Guard, Gen. Hossein Salami; and the head of the Guard’s aerospace division, which oversees its arsenal of ballistic missile program, Gen. Amir Ali Hajizadeh.

Two of Bagheri’s deputies were also killed, Iran confirmed Saturday. On Saturday, Khamenei named a new leader for the Revolutionary Guard’s aerospace division: Gen. Majid Mousavi.

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What happened

Israel attacked Tehran and Iranian nuclear facilities and missile sites early Friday morning, killing the country's three top military leaders and at least two leading nuclear scientists. Israeli officials said the attack, involving 200 warplanes that hit more than 100 targets, was a "preemptive" strike on Iran's nuclear program. Secretary of State Marco Rubio said Israel "took unilateral action" and the U.S. was "not involved in strikes against Iran."

Who said what

Iranian state media confirmed the deaths of Maj. Gen. Mohammad Bagheri, the chief of staff of Iran's armed forces; Gen. Hossein Salami, top commander of the Islamic Revolutionary Guards Corps; and deputy armed forces commander Gen. Gholamali Rashid. Israel's strike dealt a "major blow to Iran's chain of command," The New York Times said, and escalated fears that the "long-simmering tensions between the heavily armed rivals could explode into a full-blown regional war."

A spokesperson for Iran's armed forces said both Israel and the U.S. "must pay a very heavy price" and would "receive a very forceful slap." But the country's supreme leader, Ayatollah Ali Khamenei, did not mention the U.S. in a later statement, saying only that Israel "should anticipate a harsh punishment" for opening its "wicked and blood-stained hand to commit a crime against our beloved country."

"Should Iran retaliate," The Washington Post said, "it was not immediately clear whether the U.S. would assist Israel's defense, including shooting down Iranian drones and missiles as it did twice last year." A U.S. official said that decision was "up to the president." Iran subsequently fired about 100 drones in retaliation, which Israel said it was starting to intercept.

What next?

Israeli Prime Minister Benjamin Netanyahu said in a video statement that "this operation will continue for as many days as it takes" to "roll back the Iranian threat to Israel's very survival." U.S. intelligence does not share Israel's view that Iran is close to building a nuclear weapon, and President Donald Trump said Thursday he had told Netanyahu "I don't want them going in" while his administration was negotiating a nuclear deal with Tehran. Iran said Friday morning it will not participate in U.S. talks scheduled for Sunday.