Former CIA Director David Petraeus called the Iranian attack on Israel a “very big deal” in an interview Sunday on CNN’s “State of the Union.”

“Well, it is significant. It’s a very big deal. And I think Israel will have to take some action in response,” Petraeus said.

“I think it’s very clear that the U.S. would like to see that be as limited as is possible. Keep in mind that the real issue here, in addition to Israel’s security, of course, which is first and foremost, but it’s also about freedom of navigation from the Gulf or the oil and gas that come from the Gulf and fuel much of the global economy,” he continued.

Petraeus said he thinks it’s in everyone’s interest not to continue escalating the situation, noting Iran likely wants to be careful to preserve freedom of navigation in the Gulf, since they export more than a million barrels of oil each day and likely do not want to interfere with that.

“That’s the biggest issue here. And Iran, I don’t think, wants to have that disrupted either, because they export about 1.6 or 1.7 million barrels a day themselves. So, keep your eye on that. Brent Crude is already above $90 a barrel, and it would really spike if there was something that interfered with freedom of navigation,” he said. “In, fact we need to figure out what’s going on. Iran did take a ship the other day that they claimed was in some way dealing with Israel.”

“But this is another step up the rung of escalation. I think it’s in the interest of everyone to stop the increasing escalation. But we will have to see what Israel decides to do in this case,” Petraeus added.

Iran launched dozens of missiles in Israel’s direction on Saturday, the “vast majority” of which were intercepted by Israel, the U.S. and other allies.

The U.S. and other Western allies have pledged support for Israel. Petraeus noted there are many possible responses Israel can take — not all of which are as escalatory in nature.

“There’s a … whole menu of actions that they can take, not all of which are necessarily overt. They can pursue covert. They can pursue asymmetric attacks, cyberspace and so forth. And keep in mind that, of course, Washington is meeting with the other G7 countries to determine what kind of diplomatic and economic responses should follow in a coordinated effort as well,” he said.

White House on Iranian attacks: 'We don't want to see this escalate'

A drone is launched in an undisclosed area in Iran as Iran launches dozens of drones toward Israel..

The US seeking to avoid further escalations in the Middle East following Iran's attack on Israel, White House spokesman John Kirby said.

"We don’t want to see this escalate. We are not looking for a major war with Iran," Kirby, communications director of the US government's National Security Council, said on Sunday, adding that the US president had been clear he was not seeking war with Iran.

The US would continue to help Israel defend itself, Kirby said, but said that how Israel responds now will be "up to them".

The US has been Israel's staunchest ally and biggest military supporter and has repeatedly reiterated its support as tensions escalated between Israel and Iran.

It was unclear on Sunday whether Israel would respond to Iran's unprecedented direct attack the previous day, involving some 300 missiles and drones in retaliation for a suspected Israeli strike at the start of the month.

Iran's "Operation Truthful Promise" was mounted in revenge for an airstrike on its embassy grounds in Damascus on April 1 in which two generals and others were killed. Israel is believed to have carried out the attack and has not denied responsibility.

Israel has been Iran's declared arch-enemy since the Islamic Revolution of 1979.

The decades-old tensions between the two countries have escalated following the outbreak of the Gaza war in October.